---

---

 

 

 

 

 

 

 

 

 

 

 

---

---

 

CUSIP No. 48576U106

13G

Page 2 of 10 pages

1.		NAMES OF REPORTING PERSONS Chione Ltd.   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
2.		CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)   (a)    ¨ (b)    ¨
3.		SEC USE ONLY
4.		CITIZENSHIP OR PLACE OF ORGANIZATION   CYPRUS

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5.		SOLE VOTING POWER   0
	6.		SHARED VOTING POWER   10,258,079
	7.		SOLE DISPOSITIVE POWER   0
	8.		SHARED DISPOSITIVE POWER   10,258,079

9.		AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   10,258,079
10.		CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (see instructions)    ¨
11.		PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)   34.5%
12.		TYPE OF REPORTING PERSON (see instructions)   CO

CUSIP No. 48576U106

13G

Page 7 of 10 pages

 

 

	(a)	Karyopharm Therapeutics Inc.
	(b)	Address of Issuer’s Principal Executive Offices 2 Mercer Road Natick, MA 01760

 

 

	(a)	Name of Person Filing   This Statement is filed on behalf of each of the following persons (collectively, the “Reporting Persons”):   (i)    Chione Ltd. (“Chione”)   (ii)   Marcin Czernik   (iii)  Andreas Hadjimichael   (iv) Amalia Hadjimichael   (v)  Wiaczeslaw Smolokowski
	(b)	Address of the Principal Office or, if none, residence   (i)  The principal office of each of the Reporting Persons (other than Mr. Smolokowski) is Simou Menardou 8, Ria Court 8, Office 101, 6015 Larnaca, Cyprus.   (ii) The residence address of Mr. Smolokowski is Chalet Lenotchka, Chemin des Marais 1, Chesieres, Switzerland.
	(c)	Citizenship   (i)  Chione is a Cyprus corporation.   (ii) Mr. Hadjimichael and Ms. Hadjimichael are citizens of the Republic of Cyprus.   (iii) Messrs. Czernik and Smolokowski are citizens of the Republic of Poland.
	(d)	Title of Class of Securities   Common Stock
	(e)	CUSIP Number   48576U106

 

 

 

 

 

(a)		Amount beneficially owned:  10,258,079  shares. These shares of Common Stock are owned directly by Chione. Chione's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, and its sole stockholder, Wiaczeslaw Smolokowski, may be deemed to share voting and investment power and beneficial ownership of such shares of Common Stock. Each of such directors and stockholder disclaims such voting and investment power and beneficial ownership.  The number of shares listed on the cover pages of this Schedule 13G pertaining to Chione’s directors includes the shares of Common Stock owned directly by Chione, but does not include 3,193,473  shares of Common Stock (representing 10.7% of the outstanding Common Stock) owned directly by Plio Ltd., which has the same directors and as to which each of such directors may be deemed to share voting and investment power and beneficial ownership.  Each of such directors disclaims such voting and investment power and beneficial ownership.
(b)		Percent of class:  34.5%.  See item 4(a) above.
(c)		Number of shares as to which the person has:   Chione
		(i) Sole power to vote or to direct the vote  0.
		(ii) Shared power to vote or to direct the vote  10,258,079.
		(iii) Sole power to dispose or to direct the disposition of  0
		(iv) Shared power to dispose or to direct the disposition of  10,258,079
		Mr. Czernik

 

		(i) Sole power to vote or to direct the vote  0.
		(ii) Shared power to vote or to direct the vote  10,258,079.
		(iii) Sole power to dispose or to direct the disposition of  0
		(iv) Shared power to dispose or to direct the disposition of  10,258,079

 

		Mr. Hadjimichael
		(i) Sole power to vote or to direct the vote  0.
		(ii) Shared power to vote or to direct the vote  10,258,079.
		(iii) Sole power to dispose or to direct the disposition of  0
		(iv) Shared power to dispose or to direct the disposition of  10,258,079

 

		Ms. Hadjmichael
		(i) Sole power to vote or to direct the vote  0.
		(ii) Shared power to vote or to direct the vote  10,258,079.
		(iii) Sole power to dispose or to direct the disposition of  0
		(iv) Shared power to dispose or to direct the disposition of  10,258,079
		Mr. Smolokowski
		(i) Sole power to vote or to direct the vote  0.
		(ii) Shared power to vote or to direct the vote  10,258,079.
		(iii) Sole power to dispose or to direct the disposition of  0
		(iv) Shared power to dispose or to direct the disposition of  10,258,079

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CUSIP No. 048576U106

13G

Page 10 of 10 pages

 

 

	February 18, 2014
	Date
	Chione Limited, by /s/ Simon Prisk, as attorney-in-fact Marcin Czernik, by /s/ Simon Prisk, as attorney-in-fact Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in-fact Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in-fact  Wiaczeslaw Smolokowski, by /s/ Simon Prisk, as attorney-in-fact

Exhibit Index

Exhibit 24.1 - Power of Attorney, dated February 12, 2014, made by Marcin Czernik and Chione Limited in favor of Simon Prisk

Exhibit 24.2 - Power of Attorney, dated February 12, 2014, made by Andreas Hadjimichael and Chione Limited in favor of Simon Prisk

Exhibit 24.3 - Power of Attorney, dated February 12, 2014, made by Amalia Hadjimichael and Chione Limited in favor of Simon Prisk

Exhibit 24.4 - Power of Attorney, dated February 12, 2014, made by Wiaczeslaw Smolokowski  in favor of Simon Prisk

Exhibit 99.1 - Joint Filing Agreement, dated February 18, 2014, among the Reporting Persons

 

 

 

LIMITED POWER OF ATTORNEY

 

 

1.

to execute and file a Form ID on behalf of the undersigned and otherwise to secure any codes required in order for the undersigned to be able to file with the U.S. Securities and Exchange Commission’s Edgar system;

 

2.

to execute and file any Form 3, Form 4, or Form 5, Schedule 13G or 13D, any amendments to any such Form or Schedule, and any filing agreements related to securities of KTI on behalf of the undersigned and/or the Company;

 

3.

to seek and obtain information on behalf of, and as the representative of the undersigned and/or the Company, from any and all persons, including, without limitation, representatives of the Company and KTI, in connection with the foregoing; and

 

4.

to do and perform any and all acts and things, including, without limitation, to execute, submit and file such agreements, instruments, forms and other documents, to incur such expenses, as may be necessary or desirable, in the sole discretion of such attorney-in-fact, in connection with the foregoing, it being understood that the documents executed by such attorney-in-fact pursuant to this Limited Power of Attorney shall be in such form and shall contain such information as such attorney-in-fact may approve in such attorney-in-fact’s sole discretion.

 

 

 

 

 

 

 

---

 

LIMITED POWER OF ATTORNEY

 

 

1.

to execute and file a Form ID on behalf of the undersigned and otherwise to secure any codes required in order for the undersigned to be able to file with the U.S. Securities and Exchange Commission’s Edgar system;

 

2.

to execute and file any Form 3, Form 4, or Form 5, Schedule 13G or 13D, any amendments to any such Form or Schedule, and any filing agreements related to securities of KTI on behalf of the undersigned and/or the Company;

 

3.

to seek and obtain information on behalf of, and as the representative of the undersigned and/or the Company, from any and all persons, including, without limitation, representatives of the Company and KTI, in connection with the foregoing; and

 

4.

to do and perform any and all acts and things, including, without limitation, to execute, submit and file such agreements, instruments, forms and other documents, to incur such expenses, as may be necessary or desirable, in the sole discretion of such attorney-in-fact, in connection with the foregoing, it being understood that the documents executed by such attorney-in-fact pursuant to this Limited Power of Attorney shall be in such form and shall contain such information as such attorney-in-fact may approve in such attorney-in-fact’s sole discretion.

 

 

 

 

 

LIMITED POWER OF ATTORNEY

 

 

1.

to execute and file a Form ID on behalf of the undersigned and otherwise to secure any codes required in order for the undersigned to be able to file with the U.S. Securities and Exchange Commission’s Edgar system;

 

2.

to execute and file any Form 3, Form 4, or Form 5, Schedule 13G or 13D, any amendments to any such Form or Schedule, and any filing agreements related to securities of KTI on behalf of the undersigned and/or the Company;

 

3.

to seek and obtain information on behalf of, and as the representative of the undersigned and/or the Company, from any and all persons, including, without limitation, representatives of the Company and KTI, in connection with the foregoing; and

 

4.

to do and perform any and all acts and things, including, without limitation, to execute, submit and file such agreements, instruments, forms and other documents, to incur such expenses, as may be necessary or desirable, in the sole discretion of such attorney-in-fact, in connection with the foregoing, it being understood that the documents executed by such attorney-in-fact pursuant to this Limited Power of Attorney shall be in such form and shall contain such information as such attorney-in-fact may approve in such attorney-in-fact’s sole discretion.

 

 

 

 

 

2 

 

 

 

1.

to execute and file a Form ID on behalf of the undersigned and otherwise to secure any codes required in order for the undersigned to be able to file with the U.S. Securities and Exchange Commission’s Edgar system;

 

2.

to execute and file any Form 3, Form 4, or Form 5, Schedule 13G or 13D, any amendments to any such Form or Schedule, and any filing agreements related to securities of KTI on behalf of the undersigned and/or the Company;

 

3.

to seek and obtain information on behalf of, and as the representative of the undersigned and/or the Company, from any and all persons, including, without limitation, representatives of the Company and KTI, in connection with the foregoing; and

 

4.

to do and perform any and all acts and things, including, without limitation, to execute, submit and file such agreements, instruments, forms and other documents, to incur such expenses, as may be necessary or desirable, in the sole discretion of such attorney-in-fact, in connection with the foregoing, it being understood that the documents executed by such attorney-in-fact pursuant to this Limited Power of Attorney shall be in such form and shall contain such information as such attorney-in-fact may approve in such attorney-in-fact’s sole discretion.

 

 

 

 

 

 

---

Dated:  February 18, 2014

Chione Limited, by /s/ Simon Prisk, as attorney-in-fact   Marcin Czernik, by /s/ Simon Prisk, as attorney-in-fact   Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in-fact   Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in- fact   Wiaczeslaw Smolokowski, by /s/ Simon Prisk, as attorney-in-fact